On the fateful day when Nora MacDonald and George Venturi decided to get married and merge their families, there was one little detail they overlooked their two competitive teenagers. Derek Venturi and Casey MacDonald don't find their own genetic siblings a threat, but when they are forced to live together, Derek and Casey find themselves in a take-no-prisoners fight for control of their house, their school and their world. It may take some time for everyone to adjust to Life with Derek.

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